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About thrombosis
Thrombophilia: acquired thrombophilia
Paroxysmal nocturnal haemoglobinuria
Paroxysmal nocturnal haemoglobinuria is an extremely rare condition, and is due to a bone marrow disorder. It can result in a number of problems, including venous thrombosis. In this condition the red cells are prone to break down in the blood (known as haemolysis). The bone marrow then fails, leading to anaemia, low white cell counts (increasing the risk of infection) and low platelet counts.
Up to 39 per cent of individuals with this condition have venous thromboses. These thromboses are unusual, as they occur in the abdomen – usually in the liver veins – and in the veins draining the brain.
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