 |
 |
 |
 |
 |
 |
Research projects
Research into antiphospholipid
syndrome during pregnancy
Our first grant was awarded to Dr Sophia Stone, part of a team at St Thomas'
Hospital, London who have a special interest in high-risk pregnancies. Dr
Stone's study looked at pregnant women with a thrombotic condition known as
antiphospholipid syndrome.
During pregnancy, this condition can cause placental problems, which deprive the foetus of adequate nutrition so that it does not grow well and in the worse case scenario, dies in the womb.
This study tested the theory that in antiphospholipid syndrome there was interference with the lining of the mother's blood vessels. This involved taking regular blood samples from women with antiphospholipid syndrome and from healthy women during pregnancy. The team looked at their blood for evidence of markers of inflammation.
The team found that the women with antiphospholipid syndrome tended to have smaller babies and more problems during pregnancy, but there was no evidence of inflammation in their blood vessels. The study thus helped further our understanding of why women with antiphospholipid syndrome have placental problems by excluding one potential cause.
The findings of this research were published in the American Journal of Obstetrics and Gynaecology.
Stone S, Hunt BJ, Seed PT, Parmar K, Khamashta MA,
Poston L. Longitudinal evaluation of markers of endothelial cell
dysfunction and hemostasis in treated antiphospholipid syndrome and in healthy
pregnancy. Am J Obstet Gynaecol 2003 Feb; 188(2): 454-460.
top of page
Copyright
© Lifeblood: The Thrombosis Charity 2003-2006. A
company limited by guarantee. Registered Company No: 4354472.
Registered Charity No: 1090540
